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Current Analytical Chemistry
Current Analytical Chemistry
Wednesday, November 2, 2016
Highlighted Article: Solid-Phase Extraction of Ibuprofen from Pharmaceuticals via Ligand Exchange Using Zirconium Dioxide
Solid-Phase Extraction of Ibuprofen from Pharmaceuticals via Ligand Exchange Using Zirconium Dioxide
Author(s):
Michal Klivicky, Jiri Klimes and Radim Kucera Pages 523 - 528 ( 6 )
Abstract:
Background & Objective: The presence of Lewis acid sites on the metal oxides is responsible for a problematic elution of Lewis bases from these stationary phases due to the ligand exchange. The interactions are quite strong and the kinetics is relatively slow which is chromatographically undesirable. On the other hand, the interactions based on ligand-exchange could be employed in the solid-phase extraction. We newly tested these presumptions in the extraction process of ibuprofen (Lewis base) from hydrophobic suppositories as well as a hydrophilic oral suspension.
Method & Results: The pharmaceutical formulation was dissolved in hexane (suppositories) or 50 % methanol (oral suspension) and 0.5 mL of the appropriate solution was loaded on a cartridge containing bare zirconia. After washing with methanol and water, ibuprofen was eluted by 1% ammonia in methanol. It was shown that only zirconia (in contrast to titania) was capable to extract ibuprofen from pharmaceuticals thanks to the stronger ligand exchange properties. A novel method for ibuprofen extraction using zirconia was proposed. The recoveries of ibuprofen were 95 % and 94 % from suppositories and an oral suspension, respectively.
Conclusion: This paper describes the first successful utilization of ligand exchange process on zirconia in the extraction of ibuprofen from two different pharmaceuticals. It was shown the pivotal role of interactions between the carboxylic moiety and the Lewis acid sites on the zirconia surface. The procedure can be applied in case that the vehicle is not compatible with the chromatographic conditions used for the subsequent analysis of the active compound.
Keywords:
Ibuprofen, zirconia, titania, solid-phase extraction, pharmaceuticals, suppository, oral suspension.
Affiliation:
Department of Pharmaceutical Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, CZ-50005 Hradec Kralove, Czech Republic.
For More Information Please Visit Our Website Current Analytical Chemistry
Tuesday, October 25, 2016
Most Cited Article: A New Method for Measuring Total Antioxidant Capacity in Urine Using the Iodine Starch Agar Based on Agar diffusion
A New Method for Measuring Total
Antioxidant Capacity in Urine Using the Iodine Starch Agar Based on Agar
diffusion
Author(s):
Ying Zhou, Naijin Xu, Meijuan Zhang and Hui LiuPages 425-430 (6)
Abstract:
The purpose of this paper is to develop a new
method for determining total antioxidants capacity (TAC) in urine. In our
study, Na2S2O3 and mixed
urine were used to evaluate the linearity and precision of the iodine starch
agar method. The areas of urine diffusion in samples from 44 coronary heart
disease patients and 44 healthy subjects were determined by the iodine starch
agar method. The results have shown that the linearity and precision for iodine
starch agar method were acceptable, because the R2s in linear experiment of Na2S2O3 and urine
were 0.999 and 0.995, respectively; variation coefficients of urine diffusion
area in high and low levels within-run, between-run, between-day were all less
than 10%. The difference of TAC in urine between the coronary heart disease
group (Median= 0.95) and healthy group (Median= 1.13) was statistically
significant (p=0.001). The iodine starch agar method is a simple and convenient
assay to determine total antioxidant capacity in urine.
Keywords:
Iodine starch agar method (ISAM), total antioxidant capacity
(TAC), urine.
Affiliation:
College of Medical Laboratory, Dalian Medical University,
Dalian, 116004, P.R. China.
Graphical
Abstract:
For More Information Please Visit Our Website Current Analytical Chemistry
Wednesday, October 19, 2016
Podcast on An Improved Method for the Synthesis of β-Aminocarbonyl and β-Aminonitrile Compounds using Indium (III) Trifluoromethanesulphonate in Glycerol under Microwave Irradiation
Podcast on An Improved Method for the Synthesis of β-Aminocarbonyl and β-Aminonitrile Compounds using Indium (III) Trifluoromethanesulphonate in Glycerol under Microwave Irradiation
Wednesday, October 5, 2016
Enantiomeric Profiling of Chiral Pharmacologically Active Compounds in the Environment with the Usage of Chiral Liquid Chromatography Coupled with Tandem Mass Spectrometry
Enantiomeric Profiling of Chiral Pharmacologically Active Compounds in the Environment with the Usage of Chiral Liquid Chromatography Coupled with Tandem Mass Spectrometry
[ Vol. 12 , Issue. 4 ]
Author(s):
Dolores Camacho-Munoz, Bruce Petrie, Erika Castrignanò and Barbara Kasprzyk-HordernPages 303-314 (12)
Recently Published Issue of the Journal Current Analytical Chemistry
Current Analytical Chemistry publishes expert reviews and original research articles on the most recent advances in analytical chemistry. All aspects of the field are represented, including analytical methodology, techniques, and instrumentation in both fundamental and applied research topics of interest to the broad readership of the journal. Current Analytical Chemistry strives to serve as an authoritative source of information in analytical chemistry and in related applications such as biochemical analysis, pharmaceutical research, quantitative biological imaging, novel sensors, and nanotechnology.
Following are the articles from the journal Current Analytical Chemistry, 11 issue 3:
Article: Preparation and Certification of Sulfamethoxazole Reference Material by Mass Balance Method and Differential Scanning Calorimetry
Author(s): Baoxi Zhang, Ningbo Gong, Dezhi Yang, Guanhua Du, Zhaolin Gao and Yang Lu
Article: Homogenization of Self-assembled Optical Transducer Using Spiropyran Polymer
Author(s): Alicia Ortiz-Ramirez, Placido Zaca-Moran, Eugenia Jaramillo-Flores, Abdu Orduna-Diaz, Orlando Zaca-Moran, Valentin Gayou and Raul Delgado-Macuil
Article: The Detection of Pb2+ Using Glutathione Capped Mn Doped ZnS QDs
Author(s): Wei Bian, Hao Zhang, Fang Wang, Jing Ma, Yanli Wei, Shaomin Shuang and Zongwei Cai
Article: Bio-analytical Method Development and Validation of Tadalafil with a Special Emphasis on Pharmacokinetic Study in Healthy Indian Subjects for the ODS Formulation
Author(s): Shubhasis Dan, Dhiman Halder, Anwesha Barik, Easha Biswas, Murari Mohun Pal, Balaram Ghosh, Pradipta Sarkar, Chinmoy Das, Pragnya Chakraborty, Sangujkta Pradhan and Tapan Kumar Pal
Article: Greener Liquid Chromatography for Simultaneous Determination of Rosiglitazone and Glimepiride in Rat Sera and its Application to a Pharmacokinetic Study
Author(s): Mohamed Hefnawy, Nasser Algrain, Mohammed Abounassif, Sabry Attia and Yasser El-Shabrawy
Article: Adsorption of Trace Selenium on Nano-Ti2 from Natural Water Samples
Author(s): Ting Huang
Article: Influence of Two Cyclodextrin HP-derivatives on Retention and Migration Distance of Some Isomers in High- Performance Thin-Layer Chromatography and Pressurized Planar Electrochromatography Systems with Non-polar Adsorbents
Author(s): Beata Polak and Urszula Majcher
Article: Multi-Walled Carbon Nanotubes/Vitamin B12 Modified Glassy Carbon Electrode for Determination of P-hydroxyacetophenone
Author(s): Xiaojing Si, Ting Wang, Yaping Ding, Bingdi Liu and Liqiang Luo
Article: Simultaneous Determination of Gold and Palladium via Potentiometric Titration
Author(s): Stefano Caporali, Silvano Bellandi, Lorenzo Romualdi, Simone Bernardi, Massimo Innocenti and Giovanni Pezzatini
Article: Microwave-assisted Extraction Coupled with High Performance Liquid Chromatography-electrospray Ion Trap Mass Spectrometry for the Determination of Three Flavone di-C-glycosides in Viola yedoensis
Author(s): Jie Cao, Dongsheng Du, Yan Qin, Chengle Yin and Zhihong Cheng
For details, please visit: http://bit.ly/1Grd8Vg
courtesy by : Bentham Insight
Recently Published Issue of the Journal Current Analytical Chemistry
Current Analytical Chemistry publishes expert reviews and original research articles on the most recent advances in analytical chemistry. All aspects of the field are represented, including analytical methodology, techniques, and instrumentation in both fundamental and applied research topics of interest to the broad readership of the journal. Current Analytical Chemistry strives to serve as an authoritative source of information in analytical chemistry and in related applications such as biochemical analysis, pharmaceutical research, quantitative biological imaging, novel sensors, and nanotechnology.
Following are the articles from the journal Current Analytical Chemistry, 11 issue 3:
Article: Preparation and Certification of Sulfamethoxazole Reference Material by Mass Balance Method and Differential Scanning Calorimetry
Author(s): Baoxi Zhang, Ningbo Gong, Dezhi Yang, Guanhua Du, Zhaolin Gao and Yang Lu
Article: Homogenization of Self-assembled Optical Transducer Using Spiropyran Polymer
Author(s): Alicia Ortiz-Ramirez, Placido Zaca-Moran, Eugenia Jaramillo-Flores, Abdu Orduna-Diaz, Orlando Zaca-Moran, Valentin Gayou and Raul Delgado-Macuil
Article: The Detection of Pb2+ Using Glutathione Capped Mn Doped ZnS QDs
Author(s): Wei Bian, Hao Zhang, Fang Wang, Jing Ma, Yanli Wei, Shaomin Shuang and Zongwei Cai
Article: Bio-analytical Method Development and Validation of Tadalafil with a Special Emphasis on Pharmacokinetic Study in Healthy Indian Subjects for the ODS Formulation
Author(s): Shubhasis Dan, Dhiman Halder, Anwesha Barik, Easha Biswas, Murari Mohun Pal, Balaram Ghosh, Pradipta Sarkar, Chinmoy Das, Pragnya Chakraborty, Sangujkta Pradhan and Tapan Kumar Pal
Article: Greener Liquid Chromatography for Simultaneous Determination of Rosiglitazone and Glimepiride in Rat Sera and its Application to a Pharmacokinetic Study
Author(s): Mohamed Hefnawy, Nasser Algrain, Mohammed Abounassif, Sabry Attia and Yasser El-Shabrawy
Article: Adsorption of Trace Selenium on Nano-Ti2 from Natural Water Samples
Author(s): Ting Huang
Article: Influence of Two Cyclodextrin HP-derivatives on Retention and Migration Distance of Some Isomers in High- Performance Thin-Layer Chromatography and Pressurized Planar Electrochromatography Systems with Non-polar Adsorbents
Author(s): Beata Polak and Urszula Majcher
Article: Multi-Walled Carbon Nanotubes/Vitamin B12 Modified Glassy Carbon Electrode for Determination of P-hydroxyacetophenone
Author(s): Xiaojing Si, Ting Wang, Yaping Ding, Bingdi Liu and Liqiang Luo
Article: Simultaneous Determination of Gold and Palladium via Potentiometric Titration
Author(s): Stefano Caporali, Silvano Bellandi, Lorenzo Romualdi, Simone Bernardi, Massimo Innocenti and Giovanni Pezzatini
Article: Microwave-assisted Extraction Coupled with High Performance Liquid Chromatography-electrospray Ion Trap Mass Spectrometry for the Determination of Three Flavone di-C-glycosides in Viola yedoensis
Author(s): Jie Cao, Dongsheng Du, Yan Qin, Chengle Yin and Zhihong Cheng
For details, please visit: http://bit.ly/1Grd8Vg
courtesy by :Bentham Insight
Monday, July 11, 2016
A Derivative Method with Free Radical Oxidation to Predict Resveratrol Metabolites by Tandem Mass Spectrometry
Author(s):
Wangta Liu, Yow-Ling Shiue, Yi-Reng Lin, Hugo You-Hsien Lin and Shih-Shin LiangPages 300-306 (7)
Abstract:
In this study, we demonstrated an oxidative method with free radical to generate 3,5,4 -trihydroxy-transstilbene (trans-resveratrol) metabolites and detect sequentially by an autosampler coupling with liquid chromatography electrospray ionization tandem mass spectrometer (LC-ESI–MS/MS). In this oxidative method, the free radical initiator, ammonium persulfate (APS), was placed in a sample bottle containing resveratrol to produce oxidative derivatives, and the reaction progress was tracked by autosampler sequencing. Resveratrol, a natural product with purported cancer preventative qualities, produces metabolites including dihydroresveratrol, 3,4 -dihydroxy-trans-stilbene, lunularin, resveratrol monosulfate, and dihydroresveratrol monosulfate by free radical oxidation. Using APS free radical, the concentrations of resveratrol derivatives differ as a function of time. Besides simple, convenient and time- and labor saving, the advantages of free radical oxidative method of its in situ generation of oxidative derivatives followed by LC-ESI–MS/MS can be utilized to evaluate different metabolites in various conditions.
Keywords:
Free radical, metabolite, resveratrol, ammonium persulfate (APS), liquid chromatography tandem mass spectrometry (LC–MS/MS), multiple reaction monitoring (MRM).
Affiliation:
Department of Biotechnology, Kaohsiung Medical University, P.O. Box: 80708 Kaohsiung, Taiwan.
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Characterization study of tomato sauces stored in different packaging materials
Author(s):
Emilio Marengo, Eleonora Mazzucco, Elisa Robotti, Fabio Gosetti, Marcello Manfredi and Giorgio CalabresePages 1-1 (1)
Abstract:
BACKGROUND: In the last decades particular attention is devoted to packaging materials to obtain the better conditions to storage food and to preserve the organoleptic properties. METHODS: In the present study samples of tomato sauce collected in different Italian markets and preserved in different packaging materials (glass, tin and multilayer plastic containers) were chemically characterized considering the content of anions (6 species), carotenoids (lycopene, sum of alpha- and beta-carotene), flavonoids (epicatechin and quercetin), metals (41 species), total polyphenols, vitamins (C and of B-groups), and volatile profile. Different analytical techniques were employed like GC and LC with different detectors (MS and DAD), and ICP-MS and ICP-OES. All developed methods were validated and applied to different commercial products collected from local markets. RESULTS: Multivariate statistical tools (Principal Components Analysis – Discriminant Analysis, PCA – DA, Ranking PCA and Partial Least Square – Discriminant Analysis, PLS – DA) were then applied to evaluate the effect played by the different packaging on the chemical profile of the samples. The multivariate strategy adopted allowed to identify markers able to discriminate samples stored in glass, tin or multilayer plastic containers. CONCLUSION: In both cases, the differences identified between the classes of samples can be ascribed to a double effect: 1) products stored in glass preserve their content in vitamins and other important nutrients or 2) storage in glass could force manufacturers to provide a product of better quality since the product is visible to the final consumer.
Keywords:
Tomato sauce, characterization study, packaging material, multivariate statistical analysis.
Affiliation:
Department of Science and Technological Innovation, University of Piemonte Orientale, Viale Michel 11, 15121 Alessandria, Italy.
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Adsorption and Characterization of an Organic Corrosion Inhibitor for Inhibiting Carbon Steel Corrosion in Chloride Solution
Author(s):
Yu Lei, Liu Zhiyong, Yang Weibin and Wang ZixiaoPages 141-146 (6)
Abstract:
The adsorption and inhibition behaviors of an organic corrosion inhibitor (C12) on the surface of the carbon steel in chloride solution were systematically investigated by using electrochemical measurements. The results indicated that C12 exhibited inhibition and curative effects on the depassivation steel in the presence of chloride. The inhibition efficiency (IE) of C12 was also studied at different temperature. It was seen that the IE was enhanced with an increase in C12 concentration. The Gibbs free energy (ΔG) calculated based on the proposed isothermal adsorption formula for the adsorption process showed that the absorption of inhibitor on steel surface including stably chemisorption. XPS and AFM analyses suggested that after C12 being incorporated, the C12 molecular was tightly adsorbed on the steel surface, resulting in a dense layer formation. This study provides an insight into better understanding of corrosion inhibiting mechanism of C12 in the chloride solution.
Keywords:
Adsorption isotherm, carbon steel, inhibition mechanism, organic corrosion inhibitor, surface analyses.
Affiliation:
School of Civil Engineering, Yantai University, Yantai 264005, P.R. China.
Graphical Abstract:
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The Occurrence of Veterinary Pharmaceuticals in the Environment: A Review
Author(s):
Fabio Kaczala and Shlomo E. BlumPages 169-182 (14)
Abstract:
It is well known that there is a widespread use of veterinary pharmaceuticals and consequent release into different ecosystems such as freshwater bodies and groundwater systems. Furthermore, the use of organic fertilizers produced from animal waste manure has been also responsible for the occurrence of veterinary pharmaceuticals in agricultural soils. This article is a review of different studies focused on the detection and quantification of such compounds in environmental compartments using different analytical techniques. Furthermore, this paper reports the main challenges regarding veterinary pharmaceuticals in terms of analytical methods, detection/quantification of parent compounds and metabolites, and risks/toxicity to human health and aquatic ecosystems. Based on the existing literature, it is clear that only limited data is available regarding veterinary compounds and there are still considerable gaps to be bridged in order to remediate existing problems and prevent future ones. In terms of analytical methods, there are still considerable challenges to overcome considering the large number of existing compounds and respective metabolites. A number of studies highlight the lack of attention given to the detection and quantification of transformation products and metabolites. Furthermore more attention needs to be given in relation to the toxic effects and potential risks that veterinary compounds pose to environmental and human health. To conclude, the more research investigations focused on these subjects take place in the near future, more rapidly we will get a better understanding about the behavior of these compounds and the real risks they pose to aquatic and terrestrial environments and how to properly tackle them.
Keywords:
Animal husbandry, antibiotics, metabolites, veterinary pharmaceuticals, waste manure.
Affiliation:
Department of Biology and Environmental Sciences, Linnaeus University, Kalmar, Sweden.
Graphical Abstract:
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Enantiomeric Profiling of Chiral Pharmacologically Active Compounds in the Environment with the Usage of Chiral Liquid Chromatography Coupled with Tandem Mass Spectrometry
Author(s):
Dolores Camacho-Munoz, Bruce Petrie, Erika Castrignanò and Barbara Kasprzyk-HordernPages 303-314 (12)
Abstract:
The issue of drug chirality is attracting increasing attention among the scientific community. The phenomenon of chirality has been overlooked in environmental research (environmental occurrence, fate and toxicity) despite the great impact that chiral pharmacologically active compounds (cPACs) can provoke on ecosystems. The aim of this paper is to introduce the topic of chirality and its implications in environmental contamination. Special attention has been paid to the most recent advances in chiral analysis based on liquid chromatography coupled with mass spectrometry and the most popular protein based chiral stationary phases. Several groups of cPACs of environmental relevance, such as illicit drugs, human and veterinary medicines were discussed. The increase in the number of papers published in the area of chiral environmental analysis indicates that researchers are actively pursuing new opportunities to provide better understanding of environmental impacts resulting from the enantiomerism of cPACs.
Keywords:
Analysis, chiral chromatography, chiral drugs, environment, mass spectrometry, pharmaceuticals, wastewater.
Affiliation:
Department of Chemistry, University of Bath, P.O. Box: BA2 7AY, Bath, United Kingdom.
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